A Biocompatible, Heparin-binding Polycation for the Controlled Delivery of Growth Factors
نویسندگان
چکیده
Cationic peptides participate in many critical events in the body. Their importance in gene regulation, host defense, and many other processes has made them ideal targets to synthetically mimic. Over the years, a multitude of polycations have been synthesized, but a synthetic polycation that is biocompatible has yet to be realized. We created a synthesis platform that has resulted in a synthetic polycation that is orders of magnitude more biocompatible than existing polymers. This design template was inspired by the fundamental characteristics (biodegradability, natural composition) that make native cationic proteins biocompatible. This synthetic, biocompatible polycation holds the potential to improve a wide array of applications in areas from drug delivery to tissue engineering.
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